Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans
Bethany Bowring, Pooja Sethiya, Desmarini Desmarini, Sophie Lev, Lisa Tran Le, Yong‐Sun Bahn, Seung‐Heon Lee, Akio Toh‐e, Nicholas Proschogo, Tom Savage, Julianne T. Djordjevic
Abstract
Δ) PHO pathway, to investigate the impact of dysregulated phosphate homeostasis on cellular function and virulence. Our studies suggest that inhibiting the function of Pho81, which has no human homologue, would have the most detrimental impact on fungal growth in the host due to depletion of phosphate stores and ATP, irrespective of phosphate availability in the host.
Topics & Concepts
Cryptococcus neoformansVirulenceCalcineurinSignal transductionVirulence factorCell biologyMicrobiologyCryptococcusBiologyCyclin-dependent kinaseBiochemistryCellMedicineCell cycleGeneSurgeryTransplantationFungal Infections and StudiesAntifungal resistance and susceptibilityPeptidase Inhibition and Analysis