Extracellular Vesicles Derived from Adipose Stem Cells Alleviate Systemic Sclerosis by Inhibiting TGF-β Pathway
Eunae Kim, Hark Kyun Kim, Jae Hoon Sul, Jeongmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jihoon Han, Junsik Kim, Sunyoung Park, Jae Hyung Park, Yong Woo Cho, Dong‐Gyu Jo
Abstract
Additionally, we discovered that ASC-EVs can decrease the expression of α-SMA and CTGF and suppress the TGF-β pathway by inhibiting the activation of SMAD2 in dermal fibroblasts induced by TGF-β1. Finally, TGF-β1-induced dermal fibroblasts underwent selective death through ASC-EVs treatment. These results indicate that ASC-EVs could provide a therapeutic approach for preventing and reversing systemic sclerosis.
Topics & Concepts
Extracellular vesiclesAdipose tissueMedicineExtracellularTransforming growth factorInternal medicineCell biologyPharmacologyEndocrinologyBiologyExtracellular vesicles in diseaseMesenchymal stem cell researchMicroRNA in disease regulation