Inhibition of the Type III Secretion System of Salmonella enterica Serovar Typhimurium via Treatment with Fraxetin
Yunjia Shi, Zeyu Sun, Yang Liu, Jingyan Shu, Yong Zhang, Qianghua Lv, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu
Abstract
The increasingly serious problem of bacterial antibiotic resistance limits the clinical application of antibiotics, which increases the need for the development of antivirulence agents. The type III secretion system (T3SS) plays a critical role in host cell invasion and pathogenesis of Salmonella and becomes a popular target for antivirulence agents screening.
Topics & Concepts
Salmonella entericaType three secretion systemSecretionSalmonellaMicrobiologySerotypeAntibioticsBiologyPathogenesisAntibiotic resistanceBacteriaImmunologyGeneGeneticsVirulenceBiochemistrySalmonella and Campylobacter epidemiologyAntibiotic Resistance in BacteriaVibrio bacteria research studies