What Is the Evidence of the Diagnostic Criteria and Screening of Immune Checkpoint Inhibitor–Induced Myocarditis?
Franck Thuny, Marc P. Bonaca, Jennifer Cautela
Abstract
• Myocarditis is a rare, but serious, complication of immune checkpoint inhibitor therapy. • The diagnosis of immune checkpoint inhibitor–induced myocarditis is sometimes challenging because of clinical, biological, and imaging features. • Diagnostic criteria have been proposed to help clinicians, but have never been validated to date. • Some guidelines now recommend early detection by repeated troponin and ECG testing, but its role has not yet been clearly demonstrated.
Topics & Concepts
MyocarditisMedicineComplicationTroponinDiagnostic testImmune checkpointImmune systemIntensive care medicineInternal medicineImmunotherapyImmunologyPediatricsMyocardial infarctionViral Infections and Immunology ResearchCardiac Structural Anomalies and RepairAcute Myocardial Infarction Research