A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice
Yunfeng Zhou, Qian Zhao, Yixuan Zhang, Lulu Di, Xue Feng, Wangjun Xu, Wei-Ping Gao, Yukun Guo, Yangyang He, Jie‐Jian Kou, Ying� Qin, Xinmei Xie, Lida Du, Guang Han, Xiaobin Pang
Topics & Concepts
MitophagyNeuroinflammationAutophagyInflammasomeSIRT3ParkinPINK1Cell biologyNeurotoxicityMitochondrionChemistryBiologyPharmacologyImmunologySirtuinMedicineInternal medicineParkinson's diseaseInflammationBiochemistryApoptosisGeneToxicityDiseaseAcetylationAndrographolide Research and ApplicationsMedicinal Plants and NeuroprotectionNatural Compounds in Disease Treatment