Controllable mitochondrial aggregation and fusion by a programmable DNA binder
Longyi Zhu, Yi‐Ting Shen, Shengyuan Deng, Ying Wan, Jun Luo, Yan Su, Mingxu You, Chunhai Fan, Kewei Ren
Abstract
self-assembly of mitochondria can be used to successfully repair ROS-stressed neuron cells. Meanwhile, this DNA binder design is highly programmable. Customized molecular switches can be easily implanted to further achieve stimuli-triggered mitochondrial aggregation and fusion inside living cells. We believe this new type of DNA regulator system will become a powerful chemo-biological tool for subcellular manipulation and precision therapy.
Topics & Concepts
FusionMitochondrial DNADNAChemistryBiophysicsBiochemistryBiologyPhilosophyGeneLinguisticsMitochondrial Function and PathologyAdvanced biosensing and bioanalysis techniquesATP Synthase and ATPases Research