Design, synthesis and biological evaluation of new carbazole-coumarin hybrids as dual binding site inhibitors of acetylcholinesterase
Mengqiu Song, Wei Min, Jing Wang, Xinxin Si, Xiu Jun Wang, Yu‐Wei Liu, Da‐Hua Shi
Topics & Concepts
ChemistryAcetylcholinesteraseButyrylcholinesteraseCarbazoleCoumarinActive siteStereochemistryTriclinic crystal systemDocking (animal)LinkerBinding siteCholinesteraseIC50Combinatorial chemistryEnzymeAchéBiochemistryCrystal structureOrganic chemistryIn vitroPharmacologyOperating systemNursingComputer scienceMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsEnzyme function and inhibition