The WalR-WalK Signaling Pathway Modulates the Activities of both CwlO and LytE through Control of the Peptidoglycan Deacetylase PdaC in Bacillus subtilis
Genevieve S Dobihal, Josué Flores-Kim, Ian J. Roney, Xindan Wang, David Z. Rudner
Abstract
Bacterial growth and division requires a delicate balance between the synthesis and remodeling of the cell wall exoskeleton. How bacteria regulate the potentially autolytic enzymes that remodel the cell wall peptidoglycan remains incompletely understood. Here, we provide evidence that the broadly conserved WalR-WalK two-component signaling system homeostatically controls both the levels and activities of two cell wall hydrolases that are critical for cell growth.
Topics & Concepts
BiologyCell biologyBacillus subtilisPeptidoglycanSignal transductionDerepressionCellTranscription factorCell membraneBiochemistryEnzymeGene expressionGenePsychological repressionBacteriaGeneticsBacterial Genetics and BiotechnologyBacteriophages and microbial interactionsBacterial biofilms and quorum sensing