Palladium-catalyzed [4 + 4] cycloadditions for highly diastereo- and enantioselective synthesis of functionalized benzo[<i>b</i>]oxocines
Xunhua Wang, Jianfeng Yang, Ruifeng Lv, Pengfei Song, Denghui Ye, Jitian Liu, Xiaoxun Li
Abstract
An efficient palladium-catalyzed asymmetric [4 + 4] cycloaddition of highly reactive ortho -quinone methides with γ-methylidene-δ-valerolactones for the construction of functionalized eight-membered benzo[ b ]oxocine derivatives has been developed.
Topics & Concepts
ChemistryEnantioselective synthesisPalladiumCatalysisCombinatorial chemistryStereochemistryOrganic chemistryMedicinal chemistrySynthesis of Indole DerivativesOxidative Organic Chemistry ReactionsSulfur-Based Synthesis Techniques