Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis
Shuai Zhang, Ornella D. Nelson, Ian R. Price, Cheng‐Liang Zhu, Xuan Lü, Irma Fernández, Robert S. Weiss, Hening Lin
Abstract
SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.
Topics & Concepts
MetastasisCancerFunction (biology)BiochemistryMechanism (biology)Coenzyme AFatty acidFatty acid metabolismCancer metastasisBiologyChemistryCancer researchCell biologyEnzymeGeneticsPhilosophyEpistemologyReductaseMechanisms of cancer metastasisCancer Mechanisms and TherapyPeptidase Inhibition and Analysis