Modulating aptamer function by copper(<scp>ii</scp>)-mediated base pair formation
Marius H. Heddinga, Jens Müller
Abstract
the addition of Cu(II). The extent of modulation ability depends on the identity of the aptamer and on the exact location of the artificial nucleosides within the oligonucleotide sequence.
Topics & Concepts
AptamerChemistryNucleobaseOligonucleotideCombinatorial chemistryMolecular recognitionBase pairImidazoleNucleosideHydrogen bondRiboswitchRNAFunction (biology)MoleculeStereochemistryBiochemistryDNANon-coding RNAOrganic chemistryMolecular biologyGeneEvolutionary biologyBiologyAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery