Highly efficient Pyrococcus furiosus recombinant L-asparaginase with no glutaminase activity: Expression, purification, functional characterization, and cytotoxicity on THP-1, A549 and Caco-2 cell lines
Hesham Saeed, Asmaa Hemida, Nefertiti El-Nikhely, Manal Abdel-Fattah, Manal Shalaby, Ahmed Hussein, Ahmad Eldoksh, Farid S. Ataya, Nihal Aly, Nikolaos E. Labrou, Hisham A. Nematalla
Topics & Concepts
Pyrococcus furiosusRecombinant DNAChemistryMolecular biologyEnzymeIC50Affinity chromatographyAsparaginaseBiochemistryEnzyme assayCytotoxicityEnzyme kineticsBiologyIn vitroActive siteLeukemiaLymphoblastic LeukemiaArchaeaGeneticsGeneAcute Lymphoblastic Leukemia researchBiochemical and Molecular ResearchFolate and B Vitamins Research