Microwave-assisted multicomponent synthesis of antiproliferative 2,4-dimethoxy-tetrahydropyrimido[4,5-<i>b</i>]quinolin-6(7<i>H</i>)-ones
Subham G. Patel, Aday González‐Bakker, Ruturajsinh M. Vala, Paras J. Patel, Adrián Puerta, Apoorva Malik, Rakesh K. Sharma, José M. Padrón, Hitendra M. Patel
Abstract
Herein, we demonstrate a simple, rapid and green synthesis of 2,4-dimethoxy-THPQs under microwave irradiation and their antiproliferative activity, in silico ADMET and drug-likeness studies were carried out.
Topics & Concepts
Yield (engineering)DimedoneChemistryAcetic acidIn silicoMicrowave irradiationCombinatorial chemistryMicrowaveChromatographyNuclear chemistryOrganic chemistryBiochemistryMaterials scienceCatalysisComputer scienceGeneMetallurgyTelecommunicationsMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds