Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy
Megan E. Rosa‐Caldwell, Seongkyun Lim, Wesley S. Haynie, Lisa T. Jansen, Lauren Westervelt, Madeline G. Amos, Tyrone A. Washington, Nicholas P. Greene
Abstract
We present data suggesting that mitochondria-based interventions may mitigate disuse atrophy. However, the efficacy of mitochondria-based interventions may vary depending on the specific target of the intervention and the sex of the organism. Females appear to be more responsive to increased mitochondrial catalase as a potential therapeutic for mitigating disuse atrophy.
Topics & Concepts
AtrophyMedicinePhysical medicine and rehabilitationMuscle atrophyMitochondrionPhysiologyBiologyPhysical therapyInternal medicineBiochemistryIntensive Care Unit Cognitive DisordersAnesthesia and Neurotoxicity ResearchProsthetics and Rehabilitation Robotics