A Route to Lipid ALC‐0315: a Key Component of a COVID‐19 mRNA Vaccine
Fariba Saadati, Silvia Cammarone, Marco A. Ciufolini
Abstract
This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Key (lock)Yield (engineering)Component (thermodynamics)Sequence (biology)VirologyComputer scienceComputational biologyChemistryMedicineBiologyPhysicsInternal medicineBiochemistryComputer securityInfectious disease (medical specialty)ThermodynamicsDiseaseChemical Synthesis and AnalysisClick Chemistry and ApplicationsComputational Drug Discovery Methods