A Highly Efficient Monophosphine Ligand for Parts per Million Levels Pd‐Catalyzed Suzuki–Miyaura Coupling of (Hetero)Aryl Chlorides
Pui Ying Choy, On Ying Yuen, Man Pan Leung, Wing Kin Chow, Fuk Yee Kwong
Abstract
A new indolylphosphine WK‐phos has been synthesized for Pd‐catalyzed Suzuki–Miyaura coupling of (hetero)aryl chlorides with (alkyl)arylboronic acids. Comprising this newly developed ligand with palladium(II) acetate, the resulting catalyst system was found to be highly effective in facilitating the reaction even when the catalyst loading reaches parts per million levels (e.g. 10 ppm). These examples represent one of the lowest catalyst loadings reported to date of employing monophosphine (e.g. Ar‐PCy 2 ) for Suzuki–Miyaura reactions. The ligand geometry has also been well‐characterized by single‐crystal X‐ray crystallography.
Topics & Concepts
ChemistryArylCatalysisLigand (biochemistry)PalladiumSuzuki reactionCoupling reactionMedicinal chemistryAlkylPhosOrganic chemistryCombinatorial chemistryReceptorBiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques