Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication
Huichao Huang, Jun Zhao, Tingyu Wang, Shu Zhang, Yuzheng Zhou, Youliang Rao, Chao Qin, Yongzhen Liu, Yongheng Chen, Zanxian Xia, Pinghui Feng
Abstract
Herpesviruses are ubiquitous pathogens in human and establish lifelong persistence despite host immunity. The ability to evade host immune response is pivotal for viral persistence and pathogenesis.
Topics & Concepts
DeamidationBiologyInnate immune systemVirologyImmune systemRIG-IHerpes simplex virusGlutamine amidotransferaseVirusGlutamineGeneticsBiochemistryEnzymeAmino acidinterferon and immune responsesImmune Response and InflammationInflammasome and immune disorders