Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates
Shengxue Luo, Panli Zhang, Bochao Liu, Chan Yang, Chaolan Liang, Qi Wang, Ling Zhang, Xi Tang, Jinfeng Li, Shuiping Hou, Jinfeng Zeng, Yongshui Fu, Jean‐Pierre Allain, Tingting Li, Yuming Zhang, Chengyao Li
Abstract
T cell (0.39%/0.55%) to S peptides were detected in vaccinated macaques. It was concluded that prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S can safely elicit strong immunity in animals in preparation of clinical phase 1/2 trials.
Topics & Concepts
ImmunogenicityVirologyVaccinationNeutralizing antibodyAntibodyImmune systemImmunologyCD8Viral vectorMedicineImmunityPriming (agriculture)ImmunizationRhesus macaqueTiterT cellBiologyRecombinant DNAGeneBiochemistryGerminationBotanySARS-CoV-2 and COVID-19 ResearchVirus-based gene therapy researchImmunotherapy and Immune Responses