Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis
Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Ralf Lesche, Joern Toedling, Thibaud Jourdan, Johannes Haybaeck, Nicole Golob‐Schwarzl, Dominik Mumberg, David Henderson, Balázs Győrffy, Christian Regenbrecht, Ulrich Keilholz, Reinhold Schäfer, Martin Lange
Abstract
may provide a therapeutic differentiation strategy to eliminate CSCs and block nervous system driven disease progression.
Topics & Concepts
BiologyNeurogenesisSOX2Cancer stem cellCarcinogenesisStem cellNeural stem cellCancer researchRegulatorNeural crestCellular differentiationCancerEmbryonic stem cellCell biologyGeneGeneticsEmbryoCancer Cells and MetastasisCancer, Stress, Anesthesia, and Immune ResponseAxon Guidance and Neuronal Signaling