Alternative DNA Structures <i>In Vivo</i> : Molecular Evidence and Remaining Questions
Lucie Poggi, Guy‐Franck Richard
Abstract
Duplex DNA naturally folds into a right-handed double helix in physiological conditions. Some sequences of unusual base composition may nevertheless form alternative structures, as was shown for many repeated sequences in vitro . However, evidence for the formation of noncanonical structures in living cells is difficult to gather.
Topics & Concepts
BiologyComputational biologyDNAIn vivoEvolutionary biologyGeneticsCRISPR and Genetic EngineeringAnimal Genetics and ReproductionDNA and Nucleic Acid Chemistry