APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells
Mingjue Chen, Tetsuo Mashima, Taichi Oishi, Yukiko Muramatsu, Yosuke Seto, Manabu Takamatsu, Naomi Kawata, Shun Morino, Ayane Nakamura, Saori Inaba, Xunmei Yuan, Kohei Maruyama, Mai Suzuki, Ayana Sato, Haruka Yoshida, Myung-Kyu Jang, Anna Mizutani, Kengo Takeuchi, Kensei Yamaguchi, Fumiyuki Shirai, Satoshi Nagayama, Ryohei Katayama, Hiroyuki Seimiya
Topics & Concepts
Wnt signaling pathwayKRASCancer researchColorectal cancerCateninCarcinogenesisMutationMutantBiologyCancerBeta-cateninMolecular biologyMedicineSignal transductionGeneticsGeneWnt/β-catenin signaling in development and cancerCancer Cells and MetastasisProtein Kinase Regulation and GTPase Signaling