Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity
Neeharika Nemani, Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, R. Karthik, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity, Pragya SinghMalla, Kalimuthusamy Natarajanseenivasan, Robert Hooper, Chris E. Shannon, Warren G. Tourtellotte, Brij B. Singh, William Reeves, Kumar Sharma, Luke Norton, Subramanya Srikantan, Jonathan Soboloff, Muniswamy Madesh
Abstract
Nutrient stress triggers transcriptional changes that limit Ca 2+ influx into mitochondria through the MCU.
Topics & Concepts
MitochondrionFlux (metallurgy)Beta oxidationCell biologyChemistryPyruvate dehydrogenase complexBiochemistryFatty acidBiologyEnzymeOrganic chemistryMitochondrial Function and PathologyPancreatic function and diabetesATP Synthase and ATPases Research