The Stickland Reaction Precursor <i>trans</i> -4-Hydroxy- <scp>l</scp> -Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal <i>Clostridia</i>
A.D. Reed, Joshua R. Fletcher, Yolanda Y. Huang, Rajani Thanissery, Alissa J. Rivera, Ruth Parsons, Allison K. Stewart, Duncan J. Kountz, Aimee Shen, Emily P. Balskus, Casey M. Theriot
Abstract
may be affected by hydroxyproline metabolism, highlighting how a common nutrient may be a signal to each organism to adapt to a unique niche. Further elucidation of the differences between them in the presence of hydroxyproline and other key nutrients will be important to determining their role in nutrient competition against C. difficile.
Topics & Concepts
ClostridiaClostridioidesProlineMetabolismChemistryFood scienceBiochemistryMicrobiologyBiologyBacteriaAmino acidGeneticsClostridium difficile and Clostridium perfringens researchGut microbiota and healthHelicobacter pylori-related gastroenterology studies