Optimization of the synthetic parameters of lipid polymer hybrid nanoparticles dual loaded with darunavir and ritonavir for the treatment of HIV
Heba Elkateb, Lee Tatham, Helen Cauldbeck, Edyta Niezabitowska, Andrew Owen, Steve P. Rannard, Tom O. McDonald
Topics & Concepts
DarunavirRitonavirPLGAPolyethylene glycolBioavailabilityStabilizer (aeronautics)PolymerDispersityPoloxamerNanoparticleMaterials scienceParticle sizeChemistryPEG ratioNanomedicineChemical engineeringChromatographyNanotechnologyPolymer chemistryPharmacologyHuman immunodeficiency virus (HIV)Organic chemistryAntiretroviral therapyMedicineViral loadVirologyMechanical engineeringEngineeringFinancePhysical chemistryEconomicsCopolymerHIV/AIDS drug development and treatmentHIV-related health complications and treatmentsAdvanced Drug Delivery Systems