Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila
Xiaolan Fan, Yao Zeng, Ziqiang Fan, Liang Cui, Wenhao Song, Qi Wu, Yue Gao, Deying Yang, Xueping Mao, Bo Zeng, Mingwang Zhang, Qingyong Ni, Yán Li, Tao Wang, Diyan Li, Mingyao Yang
Abstract
lifespan. Dihydromyricetin can also lessen pERK and pAKT signaling, consequently activating FOXO and AOP to modulate longevity. Our results suggested that DHM could be used as an effective compound for anti-aging intervention, which could likely be applied to both mammals and humans.
Topics & Concepts
LongevityTranscription factorCell biologyDrosophila (subgenus)ChemistryBiologyGeneticsGeneMedicinal plant effects and applicationsAgriculture and Biological StudiesNatural product bioactivities and synthesis