Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
Ana Božović, Vesna Mandušić, Lidija Todorović, Milena Krajnović
Abstract
The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ.
Topics & Concepts
BiomarkerProstate cancerEstrogen receptorMedicineBreast cancerEndocrine systemEstrogen receptor betaEstrogenColorectal cancerBioinformaticsCancerClinical PracticeOncologyCancer researchInternal medicineBiologyHormoneBiochemistryFamily medicineEstrogen and related hormone effectsHER2/EGFR in Cancer ResearchComputational Drug Discovery Methods