The cancer hypothesis of pulmonary arterial hypertension: are polyamines the new Warburg?
Christopher J. Rhodes
Abstract
Since the identification of elevated anaerobic glycolysis in pulmonary vascular cells from patients with pulmonary hypertension (PH) led to comparisons with the Warburg effect in cancers, PH has joined the list of cardiovascular and respiratory disorders with a metabolic component to their pathology. Insulin resistance is common and associated with poor outcomes [1], and questions over the importance of prevalent metabolic syndrome remain [2]. Development of libraries of metabolites characterised with high throughput chromatography-mass spectrometry methods has facilitated the screening of large numbers of metabolites in disease tissue samples. Polyamine metabolism is a new target in pulmonary arterial hypertension also under development in cancer research <https://bit.ly/2YnD17o>