Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity.
Amira Motawea, Dalia Ahmed, Ahmed A. El‐Mansy, Noha Mohamed Saleh
Abstract
BACKGROUND: Amiodarone (AMD) is a widely used anti-arrhythmic drug, but its administration could be associated with varying degrees of pulmonary toxicity. In attempting to circumvent this issue, AMD-loaded polymeric nanoparticles (AMD-loaded NPs) had been designed. MATERIALS AND METHODS: ) was quantified using A549 and Hep-2 cell lines. In vivo assessment of the pulmonary toxicity on Sprague Dawley rats via histopathological and immunohistochemical evaluations was applied. RESULTS: -treated rats. CONCLUSION: ). Future studies may be built on these findings for diminishing AMD-induced off-target toxicities.
Topics & Concepts
Pulmonary toxicityIn vivoPLGAToxicityCytotoxicityNanoparticleMaterials scienceA549 cellChemistryBioavailabilityIn vitroBiophysicsPharmacologyBiomedical engineeringNanotechnologyMedicineBiochemistryOrganic chemistryBiologyBiotechnologyDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsAnalytical Methods in Pharmaceuticals