Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease
Yulin Liu, Giuseppe Uras, Itse Onuwaje, Wenlong Li, Hong Yao, Shengtao Xu, Xinuo Li, Xinnan Li, James B. Phillips, Stephanie Allen, Qi Gong, Haiyan Zhang, Zheying Zhu, Jie Liu, Jinyi Xu
Topics & Concepts
NeuroprotectionAcetylcholinesteraseChemistryDonepezilPharmacologyAchéOxidative stressLead compoundButyrylcholinesteraseIn vivoIC50BiochemistryCholinesteraseEnzymeIn vitroDementiaInternal medicineBiologyMedicineBiotechnologyDiseaseCholinesterase and Neurodegenerative DiseasesChemical synthesis and alkaloidsSynthesis and biological activity