PIM1 instigates endothelial-to-mesenchymal transition to aggravate atherosclerosis
Zhiwei Xue, Mengtao Han, Tao Sun, Yanzhao Wu, Wenchen Xing, Fi‐Tjen Mu, Zhihan Zhang, Junzhi Liu, Xiangjun Liang, Ling Lü, Jian Wang, Jiwei Wang, Xingang Li, Bin Huang, Donghai Wang
Abstract
Our findings revealed the PIM1/P-NDRG1(S330)/PTBP1/EndMT axis as a critical factor promoting AS progression and could generate new strategies to prevent AS.
Topics & Concepts
Mesenchymal stem cellTransition (genetics)MedicinePathologyChemistryGeneBiochemistryCancer Mechanisms and TherapyGalectins and Cancer BiologySignaling Pathways in Disease