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2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia

Sicong Xu, Yiran Zhu, Jie Meng, Chao Li, Zhenzhen Zhu, Chen Wang, Yu‐Cheng Gu, Liang Han, Jiajie Wen, Minghui Tong, Xuan Shi, Yunlei Hou, Yajing Liu, Yanfang Zhao

2023Bioorganic Chemistry11 citationsDOI

Topics & Concepts

ChemistryMyeloid leukemiaBioavailabilityMicrosomeIC50PharmacologyIn vitroPharmacokineticsApoptosisBiochemistryCancer researchMedicineBiologyMyeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia ResearchCytokine Signaling Pathways and Interactions
2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia | Litcius