C–H Borylation of Diphenylamines through Adamantane-1-carbonyl Auxiliary by BBr<sub>3</sub>
Gaorong Wu, Xiaopan Fu, Yangyang Wang, Kezuan Deng, Lili Zhang, Tao Ma, Yafei Ji
Abstract
as the boron source has been reported. The noncatalytic adamantane-1-carbonyl directed reaction exhibited site exclusivity and good functional group tolerance. Generally, the borylation occurred at the more electron-rich aromatic ring and the borylated products could be converted to various useful intermediates. Besides, the derived arylation and removal of auxiliary of the product could be achieved in a one-pot fashion.
Topics & Concepts
BorylationChemistryAdamantaneBoronRing (chemistry)Medicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryArylAlkylOrganoboron and organosilicon chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions