Enantioselective construction of a congested quaternary stereogenic center in isoindolinones bearing three aryl groups <i>via</i> an organocatalytic formal Betti reaction
Arben Beriša, Danijel Glavač, Chao Zheng, Shu‐Li You, Matija Gredičak
Abstract
An efficient enantioselective formal Betti reaction between phenols and diaryl ketimines generated in situ from isoindolinone alcohols is described.
Topics & Concepts
StereocenterEnantioselective synthesisChemistryArylOrganocatalysisCatalysisStereochemistryCombinatorial chemistryOrganic chemistryAlkylAxial and Atropisomeric Chirality SynthesisSynthesis and pharmacology of benzodiazepine derivativesAsymmetric Synthesis and Catalysis