Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads
Peng Xiao, Jianpan Huang, Xiongqi Han, Jacinth Wing‐Sum Cheu, Yang Liu, Lok Hin Law, Joseph H. C. Lai, Jiyu Li, Se Weon Park, Carmen Chak‐Lui Wong, Raymond H. W. Lam, Kannie W. Y. Chan
Abstract
< 0.01) in CEST contrast at 4.2 ppm during the first 3 days of treatment and decreased to 15.2 ± 4.8% when treatment stopped. Notably, percentage changes in Iop-lipobeads were higher than that of amide CEST (11.7% and 9.1%) in tumors during and after treatment. These findings demonstrated that the Iop-lipobead could provide an independent and sensitive assessment of the pHe changes for a noninvasive and longitudinal monitoring of the treatment effects using multiple CEST contrast.
Topics & Concepts
Microbead (research)IopamidolMagnetic resonance imagingSodium bicarbonateMaterials scienceIn vitroNuclear medicineBiomedical engineeringMedicineChemistryRadiologyContrast mediumBiochemistryPhysical chemistryLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsMRI in cancer diagnosis