A synergistic investigation of azo-thiazole derivatives incorporating thiazole moieties: a comprehensive exploration of their synthesis, characterization, computational insights, solvatochromism, and multimodal biological activity assessment
Dara M. Aziz, Sangar Ali Hassan, Alla Ahmad M. Amin, Media Noori Abdullah, Karzan Qurbani, Shujahadeen B. Aziz
Abstract
DFT calculations. Employing PASS and pkCSM platforms, we gained insights into controlling the bioactivity and physicochemical features of these compounds, highlighting their potential as new active agents.
Topics & Concepts
ThiazoleChemistryMoietyCombinatorial chemistryIn silicoDocking (animal)Antibacterial activityProtein Data Bank (RCSB PDB)Carbon-13 NMRProton NMRHydrazoneStereochemistryPotencyIn vitroBiochemistryBacteriaNursingMedicineGeneBiologyGeneticsSynthesis and biological activityComputational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds