Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma
Yanru Meng, Mengxin Zhang, Xinli Li, Xinxin Wang, Qian Dong, Hu Zhang, Yuanjun Zhai, Song Qin, Fuchu He, Chunyan Tian, Aihua Sun
Abstract
. In summary, MNDA exerts a protumor role by promoting M2 macrophages polarization and HCC metastasis, and can serve as a potential biomarker and therapeutic target for HCC.
Topics & Concepts
Hepatocellular carcinomaMetastasisCancer researchBiologyComputational biologyGeneticsCancerImmune cells in cancerMicroRNA in disease regulationCancer, Hypoxia, and Metabolism