Bioactivities and Future Perspectives of Chaetoglobosins
Jinhua Chen, Wenzhou Zhang, Qingfeng Guo, Weijiang Yu, Yongna Zhang, Baoxia He
Abstract
Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum . Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti‐inflammatory, and anti‐HIV activities . This review will comprehensively summarize the biological activities and mechanisms of action of nature‐derived chaetoglobosins.
Topics & Concepts
Engineering ethicsEngineeringMosquito-borne diseases and controlCytomegalovirus and herpesvirus researchGenomics and Phylogenetic Studies