Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos
Wei Yu, Yingsi Zhou, Yajing Liu, Wenqin Ying, Ruiming Lv, Qimeng Zhao, Haibo Zhou, Erwei Zuo, Yidi Sun, Hui Yang, Changyang Zhou
Abstract
Indiscriminate ssDNA cleavage activity of CRISPR
Topics & Concepts
CRISPREmbryoDevelopmental biologyBiologyCell biologyCleavage (geology)Human geneticsMolecular biologyGeneticsBlastomereEmbryogenesisGenePaleontologyFracture (geology)CRISPR and Genetic EngineeringGenetics, Aging, and Longevity in Model OrganismsPluripotent Stem Cells Research