PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy
Yajuan Jiao, Ning Kong, Hua Wang, Dage Sun, Sujie Dong, Xiaoyong Chen, Hao Zheng, Tong Wu, Hai Yu, Lingxue Yu, Yao‐Wei Huang, Huan Wang, Baokun Sui, Ling Zhao, Ying Liao, Wen Zhang, Guangzhi Tong, Tongling Shan
Abstract
family. PABPC4 could be regulated by SP1 and broadly inhibits the replication of CoVs by targeting the nucleocapsid (N) protein through the autophagosomes for degradation. This study significantly increases our understanding of the novel host restriction factor PABPC4 against CoV replication and will help develop novel antiviral strategies.
Topics & Concepts
Replication (statistics)CoronavirusVirologyAutophagySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyCoronavirus disease 2019 (COVID-19)Viral replication2019-20 coronavirus outbreakCell biologyGeneticsVirusMedicineApoptosisDiseasePathologyOutbreakInfectious disease (medical specialty)Autophagy in Disease and TherapyRNA Interference and Gene DeliveryCRISPR and Genetic Engineering