A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers
Kathleen Birley, Clara Leboreiro-Babe, Enrique Miranda Rota, Magdalena Buschhaus, Artemis Gavriil, Alice Vitali, Maria Alonso-Ferrero, Lee Hopwood, Lara Parienti, Gabrielle M. Ferry, Barry Flutter, Nourredine Himoudi, Kerry Chester, John Anderson
Abstract
activity in a resistant neuroblastoma model. An empirical approach to B7-H3 CAR-T discovery through screening of novel scFv sequences in CAR-T format has led to the identification of a new construct with sustained proliferative capacity warranting further evaluation.
Topics & Concepts
Chimeric antigen receptorAntibodyImmunotherapyAntigenComplementarity determining regionCancer researchCancer immunotherapyCytokineCD28CytotoxicityBiologyImmunologyChemistryImmunoglobulin light chainImmune systemIn vitroCD8BiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design