Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents
Verrill M. Norwood, Claribel Murillo-Solano, Michael G. Goertzen, Beau R. Brummel, David L. Perry, James R. Rocca, Debopam Chakrabarti, Robert W. Huigens
Abstract
Dd2 cells. These findings demonstrate the potential that vincamine ring distortion has toward the discovery of novel antimalarial agents and other therapies significant to human health.
Topics & Concepts
EC50Plasmodium falciparumMalariaRing (chemistry)Drug discoveryIn vitroChloroquineStereochemistryComputational biologyPharmacologyBiologyChemistryCombinatorial chemistryBiochemistryImmunologyOrganic chemistryMalaria Research and ControlSynthesis and Catalytic ReactionsChemical synthesis and alkaloids