Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation
Nehaal Ahmed, Richard J. Spears, Tom D. Sheppard, Vijay Chudasama
Abstract
aerobically generated radical intermediates to form new C-C bonds using acetylenic and vinyl triflones as radical acceptors. This enables access to a variety of acetylenic and vinyl substituted saturated heterocycles that are rich in synthetic value. Mechanistic studies and control reactions support an aerobic radical-based C-H activation mechanism.
Topics & Concepts
ChemistryOrganic chemistryMedicinal chemistryStereochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms