Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury
Jiangpeng Pan, Juntao Wang, Wei Wang, Ziyang Liu, Shuai Huo, Lei Yan, Wei Jiang, Fengmin Shao, Yue Gu
Abstract
). This dual-enzyme mimicry effectively alleviates mitochondrial oxidative damage, restores mitochondrial function, and inhibits apoptosis. Compared to RuCDzyme alone, TPP@RuCDzyme demonstrated significantly enhanced efficacy in alleviating glycerol-induced AKI by inhibiting oxidative stress. By leveraging the catalytic activity derived from the integration of CDs and a metallic element, this study presents a promising therapeutic strategy for AKI and other renal diseases associated with mitochondrial dysfunction.
Topics & Concepts
Oxidative stressMitochondrionMetalAcute kidney injuryKidneyMaterials scienceOxidative damageNanotechnologyChemistryMedicineInternal medicineBiochemistryMetallurgyAdvanced Nanomaterials in CatalysisCarbon and Quantum Dots ApplicationsNanocluster Synthesis and Applications