Preparation of synbiotic milk powder and its effect on calcium absorption and the bone microstructure in calcium deficient mice
Mingjie Jia, Jiayuan Luo, Bo Gao, Yunpeng Huangfu, Yihong Bao, Dehai Li, Shilong Jiang
Abstract
JJBYG12 increased by 8.15% and 94.53% compared with those of the control group. Long-term calcium deficiency led to a significant reduction in calcium absorption and bone calcium content in mice, accompanied by structural deterioration of bone trabeculae. SMP significantly improved apparent calcium absorption, increased serum calcium and phosphorus levels, and decreased ALP activity and CTX-1 levels. In the meantime, the bone mineral density increased significantly, and the number of bone trabeculae and the proliferation and differentiation of osteoblasts also increased. SMP has good dietary calcium supplementation capacity and bone remodeling ability without significant side effects on major organs. These findings provide insights into using SMP as a dietary calcium source to improve bone health.