PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis
Fan Chen, Yan Zhang, Longcai Wang, Tao Wang, Zhifa Han, Haihua Zhang, Shan Gao, Yang Hu, Guiyou Liu
Abstract
We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer's disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59-0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.
Topics & Concepts
Multiple sclerosisAlleleDiseaseAlzheimer's diseaseMedicineInternal medicineGeneticsOncologyBiologyImmunologyGeneBioinformatics and Genomic NetworksGenetic Associations and EpidemiologyAlzheimer's disease research and treatments