Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages
Yuanman Yu, Kai Dai, Zehua Gao, Wei Tang, Tong Shen, Yuan Yuan, Jing Wang, Changsheng Liu
Abstract
vessels in ischemia. Thus, both sulfated group and pentasaccharide sequence in SCS played an important role in directing the therapeutic angiogenesis, indicating that this highly bioactive biomaterial can be harnessed to treat ischemic disease.
Topics & Concepts
AngiogenesisSecretionMacrophageVascular endothelial growth factorEndogenyTherapeutic angiogenesisCancer researchNeovascularizationCell biologyVascular endothelial growth factor ABiologyImmunologyChemistryVEGF receptorsBiochemistryIn vitroAngiogenesis and VEGF in CancerProteoglycans and glycosaminoglycans researchImmune cells in cancer