The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases
Rossella Marullo, M. Castro, Shira Yomtoubian, M. Nieves Calvo-Vidal, María V. Revuelta, Jan Krumsiek, Andrew Cho, Pablo Cresta Morgado, ShaoNing Yang, Vanina A. Medina, Berta Roth, Marcelo Bonomi, Kayvan R. Keshari, Vivek Mittal, Alfredo Navigante, Leandro Cerchietti
Abstract
levels. These effects were associated with NO-dependent inhibition of GAPDH and hyperactivation of PARP upon nitrosative DNA damage. These metabolic changes ultimately impaired the repair of DNA damage induced by radiation in cancer cells while greatly sparing tumor-infiltrating lymphocytes.
Topics & Concepts
ArginineRadioresistanceGlycolysisNitric oxideRadiosensitizerCancer researchWarburg effectCancerRadiation therapyHyperactivationCancer cellDNA damageMedicineDNA repairChemistryBiologyMetabolismPharmacologyInternal medicineBiochemistryDNAAmino acidElectron Spin Resonance StudiesCancer, Hypoxia, and MetabolismTransplantation: Methods and Outcomes