Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning
Luke W. Koblan, Mandana Arbab, Max W. Shen, Jeffrey A. Hussmann, Andrew V. Anzalone, Jordan L. Doman, Gregory A. Newby, Dian Yang, Beverly Mok, Joseph M. Replogle, Albert Xu, Tyler A. Sisley, Jonathan S. Weissman, Britt Adamson, David R. Liu
Topics & Concepts
TransversionComputer scienceComputational biologyCoding (social sciences)Artificial intelligenceBase (topology)CRISPRMachine learningBiologyGeneGeneticsMathematicsMathematical analysisMutationStatisticsCRISPR and Genetic EngineeringRNA regulation and diseaseRNA and protein synthesis mechanisms