Foot-and-Mouth Disease Virus Induces Porcine Gasdermin E-Mediated Pyroptosis through the Protease Activity of 3C <sup>pro</sup>
Xujiao Ren, Mengge Yin, Qiongqiong Zhao, Zixuan Zheng, Haoyuan Wang, Zengjun Lu, Xujiao Ren, Ping Qian
Abstract
and can induce pyroptosis. Thus, this study reveals a previously unrecognized novel mechanism of pyroptosis induced by FMDV infection and might provide new insights into the design of anti-FMDV therapies and the mechanisms of pyroptosis induced by other picornavirus infections.
Topics & Concepts
PyroptosisBiologyVirologyVirusVirulenceFoot-and-mouth disease virusImmune systemDiseaseProteaseImmunologyProgrammed cell deathApoptosisGeneGeneticsEnzymeMedicinePathologyBiochemistryInflammasome and immune disordersViral Infections and Immunology ResearchImmune Cell Function and Interaction