Structure-based discovery of a small-molecule inhibitor of methicillin-resistant Staphylococcus aureus virulence
Jie Liu, Lina Kozhaya, Victor J. Torres, Derya Unutmaz, Min Lu
Abstract
against cytolysis by PVL and α-toxin and hence may serve as the basis for the development of an antivirulence agent for managing MRSA infections.
Topics & Concepts
LeukocidinMicrobiologyStaphylococcus aureusVirulenceLytic cycleBiologyToxinCytolysisAnthrax toxinImmune systemMethicillin-resistant Staphylococcus aureusPanton–Valentine leukocidinPore-forming toxinVirulence factorStaphylococcal infectionsBacteriaIn vitroVirologyCytotoxicityMicrobial toxinsVirusBiochemistryImmunologyFusion proteinRecombinant DNAGeneticsGeneAntimicrobial Resistance in StaphylococcusRNA and protein synthesis mechanismsBacterial Genetics and Biotechnology